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Intervention protocol 02

Induction chemotherapy followed by concomitant irradiation using p.o. vinorelbine with locally advanced non-small cell lung cancer. A randomized phase II study.

Objectives The high loco-regional failure rate remains to be a considerable problem in definitive radiotherapy of local advanced NSCLC even combined with chemotherapy. Further dose escalation is significantly limited by toxicity to the lungs, the esophagus and the heart. To circumvent these limitations, the radiation fields have to be minimized. This is possible if the motion of the tumour due to respiration can be accounted for during planning and therapy. A novel 4D-CT planning technique in combination with CBCT is under development and will be utilized to combine oral vinorelbine as a radioenhancer with an increased radiation dose.
Study outline (intervention) A 2 arm study with 2 dose levels of radiation combined with oral vinorelbine. Inclusion period: 1.10.2008 – 31.9.2010. 114 (2x 57) patients with stage IIB-IIIB NSCLC. End points: Local-failure free survival and toxicity
Expected impact Increased loco-regional control after definitive radiation leading to increased progression free survival and eventually overall survival for locally advanced NSCLC.
Linkages with work packages WP 5, 6. Tools from WP5 and WP6 will be used to obtain knowledge of the tumour motion due to respiration, and to locate the mid-ventilation phase which is the optimal phase for treatment planning. This allows the margins around the tumour to be decreased and thus escalation of radiation and chemotherapy dose without increased toxicity.

People involved in IP02


CIRRO-IP020109 - NARLAL - Navelbine And Radiotherapy in Locally Advanced Lung cancer

CIRRO-IP020209 - TARLAL - Tarceva And Radiotherapy in Locally Advanced Lung cancer