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IP04: Lymphoma

Reduction of risk of long-term complications of radiotherapy for lymphoma.

Objectives Quantifying risks of normal tissue complications (second cancers, cardiopulmonary disease, oesophageal stricture, hypothyroidism, xerostomia, muscular atrophy) in patients treated for early stage supradiaphragmatic Hodgkin lymphoma with either extended field conventional radiotherapy, involved node conventional radiotherapy or involved node proton therapy. Conformal fields planned with pre-chemotherapy PET/CT-scan fused with post-chemotherapy planning CT-scan.
Study outline (intervention) September 2008 – September 2011; approximately 30 patients (all patients treated for early stage, supradiaphragmatic, classic HL during 2006); DVH’s and NTCP of organs at risk with the 3 different treatment techniques
Expected impact Modification of risk estimates for patients treated with radiotherapy for early stage HL with new highly conformal radiotherapy (INRT) compared to now abandoned EFRT, which caused severe long term complications, with the aim of putting long-term risks in lymphoma patients treated with modern techniques in their proper perspective. Evaluation of the value of proton-therapy compared to INRT with regard to long-term NTCP, with the aim of possibly introducing proton-therapy for patients with HL.
Linkages with work packages WP 3, 4, 9.

Download protocol CIRRO-IP040110 - Reduction of risk of long-term complications of radiotherapy for lymphomas