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General information

Danish Center for Interventional Research in Radiation Oncology (CIRRO)

Under the direction of professor Jens Overgaard and professor Cai Grau, the research center ”Danish Center for Interventional Research in Radiation Oncology” (CIRRO) is a national platform for research in radiotherapy. The main objective of the research center is to improve the individualized radiotherapy and get the results into clinical practice.

Radiotherapy is one of the most dominating means of cancer treatment and plays an increasingly important role in the loco-regional management of many cancer types.

Over recent years great progress has been made in imaging technologies, radiotherapy delivery and biological understanding of radiotherapy effects on both normal tissue and cancer cells. However the improvements have not yet to at large extent been integrated in the current clinical practice.

The common aim of research carried out within ”Danish Center for Interventional Research in Radiation Oncology” (CIRRO) is to translate the information gained by functional imaging and improved biological understanding into meaningful clinical data which can be used directly in the clinic for individualized planning and delivery of radiotherapy.

The main results of the project will be improved knowledge about the heterogeneity in the biological characteristics of tumours, methods to detect relevant biological parameters, implementation of functional biological imaging for definition of biological contours for planning of radiotherapy, and implementation of image guided radiotherapy for delivery of additional dose to resistant sub-volumes without increasing risk of normal tissue morbidity. These results will directly benefit patients and optimize the use of resources in radiotherapy.
The projects will have a major impact on the state of knowledge of radiotherapy. Previous work by the project partners has had significant effects on international guidelines for radiotherapy. The planned projects will therefore strengthen and expand existing international collaborations, attract foreign researchers, and further heighten the national educational level in experimental and clinical radiotherapy.